F 10000CS465122101 Pages: 2

Reg No.: Name:
APJ ABDUL KALAM TECHNOLOGICAL UNIVERSITY

Seventh Semester B.Tech Degree Regular and Supplementary Examination December 2021 (2015 Scheme)

Course Code: CS465
Course Name: BIOINFORMATICS

Max. Marks: 100 Duration: 3 Hours
PARTA
Answer all questions, each carries 4 marks. Marks
1 Define bioinformatics and computation biology. (4)
2 Explain the structural difference between DNA and RNA. (4)
3 Explain any two protein sequence databases. (4)
4 Differentiate between distance and similarity matrix. (4)
5 Illustrate the various scoring matrices for nucleic acid. (4)
6 Explain the character based methods for phylogenetic tree analysis. (4)
7 What are the significances of GC content? How do you find the GC content ofa (4)
DNA sequence?
8 Explain various gene prediction methods. (4)
9 What is meant by RNA folding? Explain the different secondary structure (4)
elements of RNA.
10 Explain the structure of amino acid and its classification. (4)

PART B
Answer any two full questions, each carries 9 marks.
11 a) Explain central dogma of molecular biology and biological sequence associated (6)
with it.
b) Ifa double stranded DNA has 20 percentage Adenine, calculate the percentage (3)
of Cytosine in the DNA.

12 ३) Explain the following protein sequence databases (6)
i)Genepept
ii)Uniprot
b) Explain composite sequence databases, (3)
13 a) Classify different types of RNA and its functions. (4)
b) Explain the features of data retrieval tool Entrez (5)

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