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a)
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00000CS 465121903

GCATGCU
GATTACA
Write down the optimal global alignment between these sequences along with
optimal score.
Differentiate PAM and BLOSUM series.
Explain the significance of Hidden Markov Model in bioinformatics.
What is a phylogenetic tree? Explain the steps of UPGMA method for
phylogenetic tree construction with an example.
PART D

Answer any two full questions, each carries 12 marks.
Explain Prokaryotic Gene structure with neat diagrams.
Explain any two methods for Protein Secondary StructurePrediction.
What do you mean by Gene prediction? Explain the different strategies for
Gene Predictions.

Explain Nussinov algorithm for RNA structure prediction.

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