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Max. Marks: 100

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00000CS 465121903

Pages: 2

Name:
APJ ABDUL KALAM TECHNOLOGICAL UNIVERSITY

Seventh semester B.Tech examinations (S), September 2020

Course Code: CS465
Course Name: BIOINFORMATICS

PARTA
Answer all questions, each carries 4 marks.
What are the applications of Bioinformatics?
Explain the concept of base pairing. If the amount of thymine in genome is
30%, calculate the percentage of cytosine?
What are the features of Biological databases?
Explain the significance of sequence alignment.
Explain the importance of scoring matrix in sequence alignment.
Write note on Forward algorithm in HMM.
Explain algorithms for protein folding?
What are the purposes of regulation of Gene expressions?
With the help of a diagram explain the structure of an amino acid.
Write note on RNA polymerase in eukaryotes.
PART ‏تا‎
‎Answer any two full questions, each carries 9 marks.
Explain the bio-sequences associated with central dogma of molecular biology.
List the roles of mRNA ,tRNA and rRNA.
Write short note on primary biological databases.
Write short note on Entrez.
What do you mean by Genomics? Mention some of its applications.
PART C
Answer any two full questions, each carries 9 marks.
Using Needleman and Wunsch dynamic programming method, construct the
partial alignment score table for the following two sequences, using the
following scoring parameters: match score: +5, mismatch score: -1,

gap penalty: -2.

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Duration: 3 Hours

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