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Max. Marks: 100

10

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G1162 Pages: 2

APJ ABDUL KALAM TECHNOLOGICAL UNIVERSITY
SEVENTH SEMESTER B.TECH DEGREE EXAMINATION(S), MAY 2019

Course Code: CS465
Course Name: BIOINFORMATICS

PARTA
Answer all questions, each carries 4 marks.
Define Bioinformatics. Enumerate the applications of Bioinformatics?
Differentiate between mRNA and tRNA. If the sequence of the coding strand in
a transcription unit is written as follows:
5' -ATGCATGCATGCATGCATGCATGCATGC-3'
Write down the sequence of its mRNA.
Write short notes on nucleic acid sequence databases.
What is sequence alignment in bioinformatics? State the difference between
global alignment& local alignment.
BLAST and FASTA are two widely used tools for sequence alignment. What are
the similarities and differences in their approach?
Differentiate between a Markov model and Hidden Markov Model (HMM).
What are the various applications of HMMs in bioinformatics?
What does GC content mean? How do you find the GC content of a DNA?
Distinguish between
(ii) Positive and negative regulation of gene expression.
(iii) Start codon and stop codon
What is protein threading and how does it work?
What are the four levels of protein structure? How do they differ?

PART 0
Answer any two full questions, each carries 9 marks.

What is the central dogma of molecular biology? Explain.
What is DNA fingerprinting? Mention its applications.
Mention a highly annotated protein sequence database and describe its features.

Write short notes on
I. EMBL
11. DDBJ

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Duration: 3 Hours

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