Reg No.:

Max. Marks: 100

11

13

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b)

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8)
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b)

G192150 Pages:2

Name:

APJ ABDUL KALAM TECHNOLOGICAL UNIVERSITY

Course Code: CS465
Course Name: BIOINFORMATICS

PART A
Answer all questions, each carries 4 marks.

Differentiate Bioinformatics and Computational biology.

Differentiate nucleotides and nucleosides.

Write a short note on Composite databases with suitable examples.

How can we evaluate alignment of long multiple sequences?

What is phylogenetic analysis? Explain distance matrix method for phylogenetic
analysis.

How Viterbi algorithm solve HMM problems?

Explain how Microarrays can be used for gene analysis?

Write down the functions of RNA polymerases in prokaryotes and eukaryotes ?
Define reverse protein folding.

Write the features of the regular protein secondary structures of alpha helix and

beta pleated sheet.

PART B
Answer any two full questions, each carries 9 marks.

If a double stranded DNA has 40% of cytosine, calculate 9% of adenine in DNA.
If the sequence of the coding strand in a transcription unit is written as follows:
5‘'GCATGCATGCATGCATGCATGCAT3’. Write down the sequence of its
mRNA.

With the help of a diagram explain the concept of central dogma of molecular
biology

Describe a)JOWL b)CATH

What are biological databases? Why are they so important?

With a neat sketch describe DNA structure.

Explain Entrez in detail

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SEVENTH SEMESTER B.TECH DEGREE EXAMINATION(R&S), DECEMBER 2019

Duration: 3 Hours

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