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2 D 90239

Part C
Answer any six questions.

23. Briefly describe the mechanism of innate immunological barriers. Explain the process
of phagocytosis and inflammation.

24. List the functions of complement system. Explain the mechanism of classical pathway
of complement activation.

25. Describe the structure of immunoglobulins with the help of neat diagrams.

26. Differentiate between polyclonal and monoclonal antibodies. Explain the production
of monoclonal antibodies.

Write on the clinical manifestations of Type I hypersensitivity reactions.
Explain in detail the structure and function of secondary lymphoid organs.
Discuss the different agglutination reactions used in diagnosis.
Explain the principle of vaccination. Write briefly on the history of vaccination.
(6 x 5 = 80 marks)

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Part D
Answer any two questions.

31. Write a note on transplantation immunology. Explain the immunological reactions
leading to graft rejection.

32. Explain the principle of RIA and ELISA. Explain the methods and uses of different
types of ELISA. : i

33. Give an account on T-cell and B-cell maturation A.

(2 x 12 = 24 marks)